Tag Archives: dna

childrens hospital

TGen, Dell help children with cancer

Dell, Terascala and the Translational Genomics Research Institute (TGen) are installing state-of-the-art computing and programing specialized for human genome investigations at the National Cancer Institute (NCI).

As part of a formal collaboration, Dell is providing the Dell Genomic Data Analysis Platform, designed to deliver fast analysis of the billions of data points required when sequencing, or decoding, aspects of the human DNA and other genomic data.

TGen is providing NCI with high performance computing and bioinformatics support, as well as specialized software and tools developed over the last three years as TGen and Dell have partnered in support of pediatric cancer research programs globally, including a groundbreaking personalized medicine trial for pediatric cancer conducted by the Neuroblastoma and Medulloblastoma Translational Research Consortium (NMTRC).

NCI is providing TGen with access to more than 800 sequenced child-cancer genomes, which will be used in TGen’s ongoing pediatric cancer research.

“This is an enormous opportunity for the government to work with top private and research organizations to share information and expertise that will help guide physicians and medical benefit for children around the world. A system like this is critical in expediting patient care,” said James Lowey, TGen’s Vice President of Technology.

The mission of the Oncogenomics Section at the NCI is to harness the power of high throughput genomic and proteomic methods to improve the outcome of children with high-risk metastatic, refractory and recurrent cancers.

The new system at NCI will be used for four purposes:

1. House genomics data of well over 800 pediatric cancers, in a user friendly database.
2. RNAseq and immunohistochemistry database for the Stand Up to Cancer Pediatric Dream team.
3. Computational server for a precision therapy trial to be conducted with the Children’s Oncology Group.
4. Computational server for a precision therapy trial to be conducted with the Center for Cancer Research, NCI.

The research goals are to integrate the data, decipher the biology of these cancers and to identify and validate biomarkers and novel therapeutic targets and to rapidly translate findings to the clinic. This new system will host the largest collection of clinically annotated pediatric cancer genomic data ever to be released to the scientific community. Not only will this system enable state-of-the-art precision therapy trials for children and adults with lethal cancers, but also provide clinically annotated high-resolution genomics data for basic science research.

“With the advent of faster, low-cost genome sequencing technology, researchers now have a critical gateway to understanding the underlying molecular pathways for diseases. And for some diseases, every hour closer to discovery and result can mean the difference between life and death,” said Walker Stemple, Dell’s High Performance Computing Product Manager.

Terascala technology is present in several key areas of the new Dell computer cluster: TeraOS improves the reliability, ease of use, and performance of the Lustre storage in the solution; Terascala gateways enable a direct interface for the genome sequencers to the Lustre storage; and Terascala Support delivers optimized technical support across the entire storage appliance.

“We are very excited to be a contributor to this significant HPC advancement at the NCI,” said Steve Butler, CEO of Terascala. “The result is a much faster and more efficient workflow for NCI researchers. Our hope and belief is that NCI researchers will be able to accelerate their work resulting in a faster timeline in breakthroughs in the battle against cancer.”

When cancer has spread beyond the site of origin it becomes hard to cure. In addition, children with relapsed or refractory cancers have about a 20 percent chance of survival. Neuroblastoma, a rare cancer that strikes one in 100,000 children annually usually before the age of 5, is so deadly that it is responsible for one in seven pediatric cancer deaths. The cancer comes from the sympathetic nervous system, which controls heart rate, blood pressure and digestion, with aggressive tumors that are unique to each child.


To overcome these challenges, parents and physicians and scientists from the Neuroblastoma and Medulloblastoma Translational Research Consortium (NMTRC; https://nmtrc.org) and TGen have teamed to launch a groundbreaking personalized medicine clinical trial investigation for pediatric cancer. The trial is based on research from a group of collaborating investigators who are developing a personalized medicine process that is intended to permit near “real time” processing of information on patient tumors and prediction of best drugs for a specific patient.

This process generates more than 200 billion measurements per patient that must be analyzed, shared and stored. The computation and analysis of this information can take weeks, even months, to process. The Dell solution and TGen software decreased RNA-Seq data analysis time from 7 days to 4 hours.

healing frequencies

Frequencies-R-Us – Healing Through The Mind-Body Connection

Being able to release the frequencies of unhealthy emotions is where true healing begins.

When I was about 10 years old, I was fascinated by a TV show that was on channel 8, our local Public Broadcasting Station. I remember they showed a chicken and then they took the DNA of the chicken and somehow analyzed the sequence of the DNA and played it on a violin. I don’t know how they figured that out, but I remember that the music was beautiful and I wondered, “Is that what God sounded like when he spoke the chicken into existence?” Maybe He sang it into existence. Maybe He sung us into existence. I wonder what we might have sounded like as God sung us into existence.

As I pondered these thoughts, I started thinking about sound waves and light waves and how we can’t see them, but they affect us. I later read about how we are made up of frequencies and that everything resonates at a certain frequency. Different states of health have a frequency as do different kinds of sickness. Emotions also have frequencies that correspond to the different states of health and disease. The phrase, “as a man thinks, so is he” makes a lot of sense when you realize the connection between our thoughts and emotions and our bodies, the “mind body connection.”

I’ve been told that every disease has an emotional component attached to it and to completely heal, we need to become aware of the negative emotion, or more accurately the “decision” we made based on our thoughts and emotions, that is at the root of the disease. As healing begins in our bodies when we eat specific herbs and foods, remember that there is also an emotional component that quite likely began the disease process. Once we realize what that emotion is and are able to release it through forgiveness or whatever process we use to let it go, the frequency of that thought and emotion that matched the frequency of the sickness that was affecting us no longer has influence over us and our health. Healing our emotions is where true healing begins.

To find out more information about Nurtured Living and healing our bodies through foods and herbs based on Raphaology, visit nurturedliving.com.

Disclaimer:
The information provided in this article has not been evaluated by the FDA and is not intended to replace professional care. Specific and implied results are not guaranteed. In addition, I am not a licensed therapist, counselor or doctor, and any information in this article has come from my own experience and/or education and is meant only for educational purposes and is not intended to be used as medical advice. Your self-care for your well-being is ultimately your responsibility.