translational genomics research institute Archives

TGen, HonorHealth study new therapy for pancreatic cancer

VisionGate

Patients with advanced pancreatic cancer now have access to the new FDA approved drug, Onivyde, that produced significant overall survival rates in an international clinical study conducted in part by researchers at HonorHealth Research Institute and the Translational Genomics Research Institute (TGen). “Results from our clinical trial research showed a patient survival rate of nearly… Read More →

FDA approves cancer drug tested by TGen

Patients with advanced pancreatic cancer now have access to the new FDA approved drug, Onivyde, that produced significant overall survival rates in an international clinical study conducted in part by researchers at HonorHealth Research Institute and the Translational Genomics Research Institute (TGen). “Results from our clinical trial research showed a patient survival rate of nearly two… Read More →

Protein found in malaria could help stop cancer

brain cancer

Researchers at the Translational Genomics Research Institute (TGen) joined an international team of scientists in discovering how a protein from malaria could some day help stop cancer. Collaborators at the University of Copenhagen, while exploring why pregnant women are particularly susceptible to malaria, found that the mosquito-borne parasite that causes malaria also produces a protein that binds… Read More →

TGen teams with Barrow to find ALS biomarkers

The National Institutes of Health (NIH) has awarded a $687,087, one-year grant to Barrow Neurological Institute and the Translational Genomics Research Institute (TGen) to identify peptide, protein, and RNA biomarkers as indicators of Amyotrophic Lateral Sclerosis (ALS) progression. This degenerative disease, also known as Lou Gehrig’s disease, kills motor neurons — specialized nerve cells in the brain… Read More →

Magowitz Foundation gives $1 million for TGen

Cancer research

With a focus on supporting development of an early detection test for pancreatic cancer, the Seena Magowitz Foundation has presented $1 million to the Translational Genomics Research Institute (TGen). Dr. Daniel Von Hoff, a world leader in research and drug development, leads TGen’s pancreatic cancer research efforts. Through the Seena Magowitz Golf Classic, a well-known and… Read More →

TGen identifies genes linked to liver damage

Krauss Honored For Science

In a first-of-its-kind exploratory study, the Translational Genomics Research Institute (TGen) has identified a potential gene associated with the initiation of the most common cause of liver damage. Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver damage. In this study, published in the September edition of Translational Research, TGen scientists sequenced microRNAs (miRNAs) from… Read More →

TGen finds genes linked to pancreatic cancer survival

A study by the Translational Genomics Research Institute (TGen) and other major research institutes, found a new set of genes that can indicate improved survival after surgery for patients with pancreatic cancer. The study also showed that detection of circulating tumor DNA in the blood could provide an early indication of tumor recurrence. In conjunction with the… Read More →

TGen finds gene giving children appearance of aging

Krauss Honored For Science

Researchers at the Translational Genomics Research Institute (TGen)have identified a genetic mutation associated with the appearance of premature aging and severe loss of body fat in children. TGen’s Center for Rare Childhood Disorders found that the appearance of premature aging, a neonatal form of Progeroid syndrome, in a 3-year-old girl was caused by a mutation… Read More →

Arizona Medical Association honors TGen’s Von Hoff

Dr. Daniel D. Von Hoff, Distinguished Professor and Physician-In-Chief of the Translational Genomics Research Institute (TGen), will receive one of the top awards May 29 from the Arizona Medical Association (ArMA). Dr. Von Hoff will receive the 2015 Wallace A. Reed, M.D. Award, recognizing his accomplishments in advancing innovative cancer treatments, said Dr. Nathan Laufer,… Read More →

TGen, Phoenix Children’s Hospital look for new ways to store blood

The Translational Genomics Research Institute (TGen) and Phoenix Children’s Hospital are developing new economical methods of preserving, storing and transporting high-quality blood plasma proteins for use in diagnosing and treating disease. Under a $698,502 three-year grant from the National Institutes of Health, the Phoenix Children’s Hospital Biorepository and TGen’s Proteomics Division are using special filter… Read More →

TGen and Dell expand pediatric cancer fight

Dell has announced its extended partnership with the Translational Genomics Research Institute (TGen) to help clinical researchers and doctors globally expand the reach and impact of the world’s first Food and Drug Administration (FDA)-approved precision medicine trial for pediatric cancer. The renewed commitment includes an additional $3 million Dell grant to support continued collaboration with… Read More →

TGen study may help stop spread of Staph

Staphylococcus aureus — better known as Staph — is a common inhabitant of the human nose, and people who carry it are at increased risk for dangerous Staph infections. However, it may be possible to exclude these unwelcome guests using other more benign bacteria, according to a new study led by scientists representing the Translational… Read More →

TGen breast cancer study is journal’s most cited

At its Annual Meeting, the American Association for Cancer Research (AACR) announced that a scientific paper describing potential drug targets following the unprecedented genomic sequencing of 14 metastatic triple-negative breast cancer patients was the most cited study in 2013 of any published that year by AACR’s journal Molecular Cancer Therapeutics. In the study, genomic sequencing… Read More →

TGen brain-tumor study guides new treatments

Led by the Translational Genomics Research Institute (TGen) and UC San Francisco (UCSF), a comprehensive genetic review of treatment strategies for glioblastoma brain tumors was published May 1 in the Oxford University Press journal Neuro-Oncology.The study, Towards Precision Medicine in Glioblastoma: The Promise and The Challenges, covers how these highly invasive and almost-always-deadly brain cancers may be treated, reviews… Read More →