Ever wonder what company is going to be Arizona’s next breakout major player, following in the footsteps of homegrown game-changing companies like Carvana, GoDaddy and WebPT? Here are 10 Arizona startups to watch heading into 2026, along with two reasons each is worth watching (where publicly known):
1. Solera Health
What is does: A health-tech startup integrating digital health solutions with payers and providers to reduce healthcare cost and fragmentation.
• Its HALO platform guides users toward optimal care and helps streamline payer-provider coordination.
• Recognized repeatedly among Arizona’s best tech startups for its ability to impact healthcare delivery at scale.
2. Datavant
What is does: Focused on secure healthcare data sharing, enabling disparate systems to exchange patient data safely.
• Helps unlock insights by linking de-identified patient data across institutions, which is critical in research and care improvement.
• Its positioning in healthcare interoperability makes it a major player as data-driven care becomes more central.
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3. Persefoni
What is does: A climate-tech/ESG startup with a presence in Arizona, offering AI tools to manage carbon accounting and reporting.
• As regulatory pressure and sustainability reporting requirements grow, its product becomes increasingly essential.
• It bridges environmental impact with financial compliance—an emerging intersection many industries will watch.
4. Emerge
What is does: A logistics/freight procurement tech firm located in Scottsdale, improving transparency in freight markets.
• Uses real-time data and benchmarking to streamline freight sourcing decisions, reducing cost and inefficiency.
• Its growth reflects Phoenix’s expanding role in logistics, supply chain tech, and operations innovation.
5. Ategrity
What is does: A tech company in Arizona focused on data/technology solutions with customer-centric service in risk, insurance, or related verticals.
• It pairs tech with domain expertise to help organizations make more informed decisions.
• Because risk, underwriting, and compliance are undergoing transformation, its solutions are well positioned to scale.
6. Lessen
What is does: A Phoenix-based proptech business handling property maintenance, operations, and vendor management via a tech platform.
• By simplifying property operations across residential and commercial real estate, it is redefining facility management.
• Its rapid growth and high valuation signal strong demand in proptech for efficient building operations.
7. Qwick
What is does: Named among the best tech startups in Arizona, operating an on-demand staffing platform (e.g. hospitality or shift work).
• It matches workforce supply and demand dynamically, which is attractive in volatile labor markets. The Tech Tribune
• Its model is adaptable across sectors—hospitality, healthcare, events—making it scalable.
8. Postscript
What is does: SMS revenue platform for e-commerce, but headquartered in Arizona, showing the region’s strength in SaaS infrastructure.
• Helps e-commerce brands monetize SMS channels, an increasingly important part of customer engagement. The Tech Tribune
• Its growth highlights that Arizona is becoming a hub not only for health and logistics tech, but also SaaS and consumer tech.
9. Mosaic
What is does: A Phoenix startup recognized in the “best tech startups” list, likely in a data / analytics or vertical software space.
• Its presence indicates that niche software/analytics firms are emerging strongly in the AZ ecosystem.
• As industries increasingly need domain-specific analytics, firms like Mosaic are well positioned to capture growth.
10. Reference Medicine
What is does: Reference Medicine specializes in providing high-quality oncology biospecimens (e.g. FFPE tissue blocks, matched tumor/plasma sets) on transparent pricing terms, helping accelerate cancer research.
• With its lab headquartered in Phoenix, Reference Medicine is contributing to Arizona’s growing life-sciences cluster.
• The company is positioning itself as a “one-stop shop” for oncology specimen sourcing, filling a critical gap in the research supply chain and reducing costs for diagnostic developers.
