December 1, 2016

AZ Business Magazine

UA receives $1.5M to study cancer in firefighters

Cancer is the leading cause of death among firefighters, and the University of Arizona Mel and Enid Zuckerman College of Public Health is leading to collaborative project to develop the framework for a long-term study of cancer in firefighters.

The UA program received a $1.5 million in funding from the Department of Homeland Security Federal Emergency Management Agency Assistance to Firefighters Grant.

Firefighters are exposed to cancer-causing chemicals through both inhalation and skin absorption. Measuring these exposures and determining the mechanisms by which they cause cancer are essential steps in learning how to reduce cancer risk in firefighters.

Firefighter exposure to carcinogens occurs through inhalation of smoke, diesel exhaust and other chemical gases, vapors and particulates as well as through skin contamination. The type of fire; the specific job task; when they put on, take off and clean their gear; and potentially how they clean their skin; all can affect the extent of chemicals absorbed internally.

Since cancer has a long latency period between exposure and the onset of disease, biomarkers also are needed that can measure the early toxicological effects of carcinogen exposure when interventions to prevent disease could be effective.

“We still don’t understand which exposures are the most important and the specific cellular mechanisms by which the exposures are causing cancer. This information is necessary to determine the best ways to help prevent cancer in firefighters,” said Jeff Burgess, MD, MPH, associate dean of research and professor at the UA Zuckerman College of Public Health. Improving occupational health and safety has been the focus of his research over the past 25 years, with a special focus on firefighters, other public safety personnel and miners.

“The UA Mel and Enid Zuckerman College of Public Health is committed to promoting the health of communities in our state and throughout the world,” said UA President Ann Weaver Hart. “This grant will further the college’s mission to achieve health equity through excellence in education, research and service and will enable tremendous impact by helping to ensure the health and safety of the men and women who dedicate their lives to serving others. This is a wonderful expression of the UA’s commitment to serve our community.”

“Reducing cancer risk for those who daily protect our lives and property is a priority. This landmark study will have a far-reaching impact on the health of firefighters in the United States as well as throughout the world. Not only will we gain insights into the mechanisms for the development of cancer in firefighters, the research will lead to earlier detection and treatment—and possibly to prevention—of this threat to firefighters’ lives,” said Joe G.N. “Skip” Garcia, MD, UA senior vice president for health sciences, the Dr. Merlin K. DuVal Professor of Medicine and an elected member of the National Academy of Medicine.

This initial three-year framework study will build on recent firefighter cancer prevention studies in Arizona and Florida, adding the Boston Fire Department and three volunteer and combination (career and volunteer) fire departments in Southern Arizona to the existing fire service partners, the Tucson Fire Department and multiple fire departments in south Florida.

“Future research grants will be needed to further expand the number of firefighters participating in the study. The goal is to continue the research for 30 or more years, which is the time it takes for many cancers to occur,” said Dr. Burgess.

A cohort research study follows groups of individuals over time who are alike in many ways but differ by a certain characteristic (for example, firefighters responding to a greater number of fires over their career, compared to those with fewer responses) and compares them for a particular outcome (such as cancer). The new study also will focus on identifying epigenetic (nongenetic influences on gene expression) changes in firefighters, comparing them with a set of nonfirefighting “controls,” individuals with similar age, gender, race and ethnicity. Epigenetic changes are believed to be responsible for the majority of human cancers.

“The work not only will help the fire service better understand how we are being exposed to carcinogens, it will lead to safer practices on fire incidents and improved protective equipment that ultimately will lead to fewer firefighter fatalities,” said Chief Ron Siarnicki, executive director of the National Fallen Firefighters Foundation.