Tag Archives: genomic research

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PCH forms pediatric genomics institute

Dr. Patrick Soon-Shiong joined Phoenix Children’s Hospital to announce the formation of a visionary institute, The Chan Soon-Shiong Children’s Precision Medicine Institute at Phoenix Children’s Hospital.

The new partnership brings together the medical expertise and resources of renowned surgeon and healthcare technology visionary Patrick Soon-Shiong, MD, with Phoenix Children’s commitment to genomic research and access to a large pediatric patient base. The institute will transform the pediatric health care landscape by applying state-of-the-art genomic and proteomic technology to identify precision diagnoses, treatments and cures for young patients facing serious illnesses.

“Our goal is to bring genomics research to the forefront of pediatrics,” said Robert L. Meyer, president and CEO of Phoenix Children’s Hospital. “With Dr. Soon-Shiong’s transformative technology implemented at Phoenix Children’s, the realization of all children having access to life-saving precision medicine becomes one step closer.”

Soon-Shiong is the founder of Nantworks, largely dedicated to applying genomic and proteomic analysis studies to translate diagnoses and cures more quickly and accurately. To date, his efforts have been focused on the adult population. Through this institute, Phoenix Children’s will serve as the exclusive national hub for pediatric genomic research and translational precision medicine.

“Phoenix Children’s is unique among children’s hospitals,” noted Dr. Soon-Shiong. “The leadership and the board of this hospital are leading their peers in health care by executing on an operational principle of patient centered 21st century care. They have attracted talented researchers and clinical scientists and have demonstrated their ability to advance a vision for precision medicine in pediatrics.”

At the crux of this revolutionary undertaking is super computing cloud based technology and artificial intelligence. Phoenix Children’s will be home to one of the few dedicated supercomputers in the country, which can deliver genomic sequencing and analysis more quickly than ever before. Appropriate patients undergo full genome sequencing and proteomics analysis in an unprecedented seven days.

“Current genome sequencing takes time,” added Meyer. “And that’s something that these patients don’t have. The mission is to develop innovative and effective diagnostics and therapies for young patients, while empowering physicians with the most up-to-date research and therapeutic models available, all to deliver potentially life-saving treatments.”

Often, existing treatment protocols lack efficacy for patients; this new genomic analysis will alter that dynamic through specific and targeted therapeutic remedies based on the individual’s unique genetic makeup. In time, Soon-Shiong’s technology will lead to a comprehensive genomic database platform, from which a shared information consortium will be integrated into a global diagnosis, treatment, and result-based methodology. A vast bank of pediatric patient data will be generated via a consortium of children’s hospitals, led by Phoenix Children’s.

“The Chan Soon-Shiong Children’s Precision Medicine Institute will fundamentally alter the way pediatric health care is delivered around the world,” said Meyer.

Conquering Concussions

ASU, TGen Team Up for Concussion Research

Riddell, the leader in football helmet technology and innovation, and the Translational Genomics Research Institute (TGen), a leader in cutting-edge genomic research, today announced that the Pac-12’s Arizona State University and its Sun Devil football program will again participate in a genetic research study designed to advance athlete concussion detection and treatment.

Now in its second year, the joint research project will combine molecular information and head impact data from Sun Devil football student-athletes to identify whether the effects of sub-concussive hits are identifiable. The researchers will monitor the players’ changing molecular information throughout a season of typical head impact exposure associated with football practice and games. Representatives from the Sun Devil medical team and TGen will collect the molecular samples from the participating athletes, all of whom volunteered to partake in the study.

“This partnership represents another dynamic and innovative step toward ensuring that the health and well-being of our student-athletes remains our most important goal,” Vice President for Arizona State University Athletics Ray Anderson said. “Sun Devil Athletics continues to serve as a pioneering force in this important issue and is proud to participate in this world-class research study for the second consecutive year with two outstanding industry trendsetters in Riddell and TGen.”

Arizona State’s preferred helmet and protective equipment provider, Riddell, has again deployed its Sideline Response System (SRS) to obtain real-time head impact data from Arizona State football student-athletes. Riddell SRS provides researchers with a wide range of valuable information on the frequency and severity of head impacts a player receives during games and practices. Data gathered from the system will be combined with genetic information from players that experience concussion, with the objective of helping physicians diagnose concussion and better identify when a player might be expected to recover and return to the field.

“Player protection has become an essential part of football, and this cutting-edge partnership sets ASU apart from not only the rest of the conference, but every collegiate football program in the nation,” ASU Head Coach Todd Graham said. “We are not only looking out for our student-athletes while they are enrolled at ASU, but for the rest of their lives. You become a part of the brotherhood once you put on the maroon and gold, and that doesn’t end at graduation.”

Riddell will also utilize the player head impact data collected from the ASU and TGen research partnership to inform the development of new football helmets and further refine updates to smart helmet technologies like Riddell SRS and its recently launched Riddell InSite Impact Response System.

“We’re impressed by the enthusiasm exhibited by our partners, Arizona State University and TGen, as we enter the second season of our important research collaboration,” President of Riddell Dan Arment said. “They have matched our level of passion for football, and we are all committed to better protecting those that play the sport we love. We are left encouraged following the first year of our project and look forward to continuing on the path towards advancing concussion detection and treatment of athletes.”

The researchers at TGen are exploring whether the effects of sub-concussive hits are identifiable through blood-based molecular information. Their findings could prove pivotal to the game of football and other sports. Similar to last season, during this phase of the study the TGen faculty and staff are on the sidelines collecting samples and data. A baseline sample was collected from all participating players prior to their pre-season workouts. Since then, the researchers have followed the team through their daily workouts and will continue throughout the season.

Through the collection of samples over various points in time and the data generated by Riddell SRS, the goal is to identify the genomic changes in athletes exposed to routine head impacts during practice and games, athletes with diagnosed concussions that recover on both a routine time scale, and athletes with persistent symptoms following concussion that require additional treatment.

“As the mother of a young son who has played football, I’m keenly aware of the need to improve the current standards in place today for dealing with this issue,” said TGen Associate Professor Dr. Kendall Van Keuren-Jensen, whose technique for studying the collected samples drives this unique partnership. “As a researcher whose daily work looks for ways to determine the early warning signs of head injury, I get to see first hand how committed Arizona State University and Riddell are to student-athlete safety, and their determination to improve the game at all levels.”

Following the season long campaign, the researchers will gather post-season data and begin the analysis process with their colleagues at Barrow Neurological Institute and A.T. Still University. During this process, TGen will work closely with Barrow, whose B.R.A.I.N.S. (Barrow Resource for Acquired Injury to the Nervous System) program treats patients who have sustained a traumatic brain or spinal cord injury. The Barrow data will provide the researchers with additional concussion data and allow for comparison between data sets.